Article
Large T antigen variants of human polyomaviruses 9 and 12 and seroreactivity against their N terminus.
The Journal of general virology - 1 Apr 2017
Korup-Schulz Sarah-Verena, Lucke Claudia, Moens Ugo, Schmuck Rosa, Ehlers Bernhard
Abstract excerpt
The tumour antigens (TAgs) of mammalian polyomaviruses (PyVs) are key proteins responsible for modulating the host cell cycle and are involved in virus replication as well as cell transformation and tumour formation. Here we aimed to identify mRNA sequences of known and novel TAgs encoded by the recently discovered human polyomaviruses 9 and 12 (HPyV9 and HPyV12) in cell culture. Synthetic viral genomes were...
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