Article
Genetic variation in the glucocorticoid pathway involved in interindividual differences in the glucocorticoid treatment.
Pharmacogenomics - 1 Feb 2017
Song Qian-Qian, Xie Wan-Ying, Tang Yong-Jun, Zhang Jun, Liu Jie
Abstract excerpt
Glucocorticoids (GCs) are widely used for treating asthma, rheumatoid arthritis, nephrotic syndrome, acute lymphoblastic leukemia and other autoimmune diseases. However, in a subgroup of patients, failure to respond to GCs is known as GC resistance or GC insensitivity. This represents an important barrier to effective treatment and a clinical problem requiring an urgent solution. Genetic variation in the GC...
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