Article
MHC class II restricted neoantigen: A promising target in tumor immunotherapy.
Cancer letters - 28 Apr 2017
Sun Zhichen, Chen Fangjun, Meng Fanyan, Wei Jia, Liu Baorui
Abstract excerpt
Neoantigen is a patient-specific tumor antigen resulted from mutations during oncogenesis. Emerging data suggested that immune responsiveness against neoantigens correlated with the success of clinical tumor immunotherapies. Nowadays, the majority of studies on neoantigens have focused on MHC class I restricted antigens recognized by CD8+ T cells. With improved understanding of the underlying principles of tumor...
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