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Article

Biomarkers of extracellular matrix turnover are associated with emphysema and eosinophilic-bronchitis in COPD

19 Jan 2017

Abstract excerpt

BACKGROUND: Chronic obstructive pulmonary disease (COPD) is characterized by airflow obstruction and loss of lung tissue mainly consisting of extracellular matrix (ECM). Three of the main ECM components are type I collagen, the main constituent in the interstitial matrix, type VI collagen, and elastin, the signature protein of the lungs. During pathological remodeling driven by inflammatory cells and proteases,...

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Share to Asthma and respiratory diseases
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PMID: 28103932
DOI: 10.1186/s12931-017-0509-x

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