Evolutionary dynamics of non-GII genotype 4 (GII.4) noroviruses reveal limited and independent diversification of variants.

doi:10.1099/jgv.0.001088

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Article

Evolutionary dynamics of non-GII genotype 4 (GII.4) noroviruses reveal limited and independent diversification of variants.

The Journal of general virology - 1 Aug 2018

Tohma Kentaro, Lepore Cara J, Ford-Siltz Lauren A, Parra Gabriel I

Abstract excerpt

Noroviruses are extremely diverse, with ≥30 genotypes infecting humans. GII genotype 4 (GII.4) noroviruses, the most prevalent genotype, present a constant accumulation of mutations on the major capsid protein (VP1), resulting in the chronological emergence of new variants every 2-8 years. On the other hand, non-GII.4 noroviruses present a limited number of changes on the capsid protein over time. Despite limited...

Topics

Evolution, Molecular
Genetic Variation
Genotype
Humans
Norovirus
Phylogeny

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Open in PubMed

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PMID: 29916802
DOI: 10.1099/jgv.0.001088

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