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Article

A broadly protective therapeutic antibody against influenza B virus with two mechanisms of action

19 Jan 2017

Abstract excerpt

Influenza B virus (IBV) causes annual influenza epidemics around the world. Here we use an in vivo plasmablast enrichment technique to isolate a human monoclonal antibody, 46B8 that neutralizes all IBVs tested in vitro and protects mice against lethal challenge of all IBVs tested when administered 72 h post infection. 46B8 demonstrates a superior therapeutic benefit over Tamiflu and has an additive antiviral...

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PMID: 28102191
DOI: 10.1038/ncomms14234

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