Article
Variants on chromosome 4q21 near PKD2 and SIBLINGs are associated with dental caries.
Journal of human genetics - 1 Apr 2017
Eckert Scott, Feingold Eleanor, Cooper Margaret, Vanyukov Michael M, Maher Brion S, Slayton Rebecca L, Willing Marcia C, Reis Steven E, McNeil Daniel W, Crout Richard J, Weyant Robert J, Levy Steven M, Vieira Alexandre R, Marazita Mary L, Shaffer John R
Abstract excerpt
A recent genome-wide association study (GWAS) for dental caries nominated the chromosomal region 4q21 near ABCG2, PKD2 and the SIBLING (small integrin-binding ligand N-linked glycoprotein) gene family. In this investigation, we followed up and fine-mapped this region using a tag-SNP (single-nucleotide polymorphism) approach in 13 age- and race-stratified samples from 6 independent studies (N=4089). Participants...
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