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Article

Modeling the differential phenotypes of spinal muscular atrophy with high-yield generation of motor neurons from human induced pluripotent stem cells.

Oncotarget - 27 Jun 2017

Lin Xiang, Li Jin-Jing, Qian Wen-Jing, Zhang Qi-Jie, Wang Zhong-Feng, Lu Ying-Qian, Dong En-Lin, He Jin, Wang Ning, Ma Li-Xiang, Chen Wan-Jin

Abstract excerpt

Spinal muscular atrophy (SMA) is a devastating motor neuron disease caused by mutations of the survival motor neuron 1 (SMN1) gene. SMN2, a paralogous gene to SMN1, can partially compensate for the loss of SMN1. On the basis of age at onset, highest motor function and SMN2 copy numbers, childhood-onset SMA can be divided into three types (SMA I-III). An inverse correlation was observed between SMN2 copies and the...

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Source

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Identifiers

PMID: 28159932
DOI: 10.18632/oncotarget.14925
PMCID: PMC5522047

Genes

SMN2
SMN1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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