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Article

Effects of functional CYP2C8,CYP2C9,CYP3A5,and ABCB1 genetic variants on the pharmacokinetics of insulin sensitizer pioglitazone in Chinese Han individuals.

Pharmacogenetics and genomics - 1 Apr 2017

Yin Sheng-Ju, Qi Hui-Min, Wang Xin, Zhang Pu, Lu Yuan, Wei Min-Ji, Li Pu, Qi Guang-Zhao, Lou Ya-Qing, Lu Chuang, Zhang Guo-Liang

Abstract excerpt

BACKGROUND AND OBJECTIVES: Pioglitazone is a thiazolidinedione antihyperglycemic drug with insulin-sensitizing properties. We investigated whether the variant genotypes of cytochrome P450 2C8 (CYP2C8), CYP2C9, CYP3A5 and transporter ABCB1 influence the pharmacokinetic phenotype of the substrate pioglitazone in Chinese individuals. PARTICIPANTS AND METHODS: Single-nucleotide polymorphisms were determined by the...

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Identifiers

PMID: 28099407
DOI: 10.1097/FPC.0000000000000265

Genes

ABCB1

Variants

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