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Inhibition of Pax2 Transcription Activation with a Small Molecule that Targets the DNA Binding Domain

17 Jan 2017

Abstract excerpt

The Pax gene family encodes DNA binding transcription factors that control critical steps in embryonic development and differentiation of specific cell lineages. Often, Pax proteins are re-expressed or ectopically expressed in cancer and other diseases of abnormal proliferation, making them attractive targets for tissue specific inhibition by small molecules. In this report, we used a homology model of the Pax2...

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PMID: 28094913
DOI: 10.1021/acschembio.6b00782

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