Article
Targeted DNA sequencing and in situ mutation analysis using mobile phone microscopy.
Nature communications - 17 Jan 2017
Kühnemund Malte, Wei Qingshan, Darai Evangelia, Wang Yingjie, Hernández-Neuta Iván, Yang Zhao, Tseng Derek, Ahlford Annika, Mathot Lucy, Sjöblom Tobias, Ozcan Aydogan, Nilsson Mats
Abstract excerpt
Molecular diagnostics is typically outsourced to well-equipped centralized laboratories, often far from the patient. We developed molecular assays and portable optical imaging designs that permit on-site diagnostics with a cost-effective mobile-phone-based multimodal microscope. We demonstrate that targeted next-generation DNA sequencing reactions and in situ point mutation detection assays in preserved tumour...
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