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Article

In vivo optical imaging-guided targeted sampling for precise diagnosis and molecular pathology.

Scientific reports - 30 Nov 2021

Sahu Aditi, Oh Yuna, Peterson Gary, Cordova Miguel, Navarrete-Dechent Cristian, Gill Melissa, Alessi-Fox Christi, Gonzalez Salvador, Phillips William, Wilson Steven, Afzalneia Reza, Rose Raven, Mohsen Abu-Akeel, Bello Danielle, Marghoob Ashfaq, Rossi Anthony, Wolchok Jedd D, Merghoub Taha, Rotemberg Veronica, Jason Chen Chih-Shan, Rajadhyaksha Milind

Abstract excerpt

Conventional tissue sampling can lead to misdiagnoses and repeated biopsies. Additionally, tissue processed for histopathology suffers from poor nucleic acid quality and/or quantity for downstream molecular profiling. Targeted micro-sampling of tissue can ensure accurate diagnosis and molecular profiling in the presence of spatial heterogeneity, especially in tumors, and facilitate acquisition of fresh tissue for...

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PMID: 34848749
DOI: 10.1038/s41598-021-01447-4
PMCID: PMC8633337

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