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Article

AIB1 is a novel target of the high‐risk HPV E6 protein and a biomarker of cervical cancer progression

18 Apr 2022

Abstract excerpt

The high-risk human papillomaviruses (HPV-16, -18) are critical etiologic agents in human malignancy, most importantly in cervical cancer. These oncogenic viruses encode the E6 and E7 proteins that are uniformly retained and expressed in cervical cancers and required for maintenance of the tumorigenic phenotype. The E6 and E7 proteins were first identified as targeting the p53 and pRB tumor suppressor pathways,...

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PMID: 35437795
DOI: 10.1002/jmv.27795

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