Article
Dissociation of Survival, Proliferation, and State Control in Human Hematopoietic Stem Cells.
Stem cell reports - 10 Jan 2017
Knapp David J H F, Hammond Colin A, Miller Paul H, Rabu Gabrielle M, Beer Philip A, Ricicova Marketa, Lecault Véronique, Da Costa Daniel, VanInsberghe Michael, Cheung Alice M, Pellacani Davide, Piret James, Hansen Carl, Eaves Connie J
Abstract excerpt
The role of growth factors (GFs) in controlling the biology of human hematopoietic stem cells (HSCs) remains limited by a lack of information concerning the individual and combined effects of GFs directly on the survival, Mitogenesis, and regenerative activity of highly purified human HSCs. We show that the initial input HSC activity of such a purified starting population of human cord blood cells can be fully...
Topics
- Animals
- Biomarkers
- Cell Differentiation
- Cell Proliferation
- Cell Survival
- Cells, Cultured
- Hematopoietic Stem Cell Transplantation
- Hematopoietic Stem Cells
- Humans
- In Vitro Techniques
- Integrin alpha6
- Intercellular Signaling Peptides and Proteins