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Article

RAD51 Is a Selective DNA Repair Target to Radiosensitize Glioma Stem Cells

1 Jan 2017

Abstract excerpt

Patients with glioblastoma die from local relapse despite surgery and high-dose radiotherapy. Resistance to radiotherapy is thought to be due to efficient DNA double-strand break (DSB) repair in stem-like cells able to survive DNA damage and repopulate the tumor. We used clinical samples and patient-derived glioblastoma stem cells (GSCs) to confirm that the DSB repair protein RAD51 is highly expressed in GSCs,...

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PMID: 28076755
DOI: 10.1016/j.stemcr.2016.12.005

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