Article
A synthetic, species-specific activator of secondary metabolism and sporulation in Streptomyces coelicolor.
Chembiochem : a European journal of chemical biology - 2 Jan 2013
Ahmed Salman, Craney Arryn, Pimentel-Elardo Sheila M, Nodwell Justin R
Abstract excerpt
The secondary metabolites produced by bacterial species serve many clinically useful purposes, and Streptomyces have been an abundant source of such compounds. However, a poor understanding of their regulatory cascades leads to an inability to isolate all of the secondary metabolites this genus is capable of producing. This study focuses on comparing synthetic small molecules that were found to alter the...
Topics
- Benzene
- Fatty Acids
- Hyphae
- Phenotype
- Small Molecule Libraries
- Species Specificity
- Spores, Bacterial
- Streptomyces coelicolor
- Structure-Activity Relationship