Activity-Independent Discovery of Secondary Metabolites Using Chemical Elicitation and Cheminformatic Inference

Abstract excerpt

Most existing antibiotics were discovered through screens of environmental microbes, particularly the streptomycetes, for the capacity to prevent the growth of pathogenic bacteria. This "activity-guided screening" method has been largely abandoned because it repeatedly rediscovers those compounds that are highly expressed during laboratory culture. Most of these metabolites have already been biochemically...

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