Article
Genetic Ablation of Soluble TNF Does Not Affect Lesion Size and Functional Recovery after Moderate Spinal Cord Injury in Mice.
Mediators of inflammation - 1 Jan 2016
Ellman Ditte Gry, Degn Matilda, Lund Minna Christiansen, Clausen Bettina Hjelm, Novrup Hans Gram, Flæng Simon Bertram, Jørgensen Louise Helskov, Suntharalingam Lujitha, Svenningsen Åsa Fex, Brambilla Roberta, Lambertsen Kate Lykke
Abstract excerpt
Traumatic spinal cord injury (SCI) is followed by an instant increase in expression of the microglial-derived proinflammatory cytokine tumor necrosis factor (TNF) within the lesioned cord. TNF exists both as membrane-anchored TNF (mTNF) and as cleaved soluble TNF (solTNF). We previously demonstrated that epidural administration of a dominant-negative inhibitor of solTNF, XPro1595, to the contused spinal cord...
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