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Article

SHARPIN Facilitates p53 Degradation in Breast Cancer Cells

5 Jan 2017

Abstract excerpt

The ubiquitin binding protein SHAPRIN is highly expressed in human breast cancer, one of the most frequent female malignancies worldwide. Here, we perform SHARPIN depletion in breast cancer cells together with RNA sequencing. The global expression profiling showed p53 signaling as a potential SHARPIN target. SHARPIN depletion decreased cell proliferation, which effect could be rescue by p53 knocking down....

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PMID: 28063307
DOI: 10.1016/j.neo.2016.12.002

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