Article
Targeting Elastase for Molecular Imaging of Early Atherosclerotic Lesions.
Arteriosclerosis, thrombosis, and vascular biology - 1 Mar 2017
Glinzer Almut, Ma Xiaopeng, Prakash Jaya, Kimm Melanie A, Lohöfer Fabian, Kosanke Katja, Pelisek Jaroslav, Thon Moritz P, Vorlova Sandra, Heinze Katrin G, Eckstein Hans-Henning, Gee Michael W, Ntziachristos Vasilis, Zernecke Alma, Wildgruber Moritz
Abstract excerpt
OBJECTIVE: Neutrophils accumulate in early atherosclerotic lesions and promote lesion growth. In this study, we evaluated an elastase-specific near-infrared imaging agent for molecular imaging using hybrid fluorescence molecular tomography/x-ray computed tomography. APPROACH AND RESULTS: Murine neutrophils were isolated from bone marrow and incubated with the neutrophil-targeted near-infrared imaging agent...
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