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Article

Electrophoretically silent hemoglobin mutants as revealed by isoelectric focusing in immobilized pH gradients.

Electrophoresis - 1 Jan 2000

Righetti P G, Gianazza E, Bianchi-Bosisio A, Wajcman H, Cossu G

Abstract excerpt

The applications of isoelectric focusing in immobilized pH gradients to the analysis of (i) human hemoglobin mutants, (ii) animal hemoglobin mutants (from cattle, sheep, dog and mouse), and (iii) tryptic digests of alpha and beta chains, are discussed and evaluated. Immobilized pH gradients appear to be an excellent tool for screening of genetic polymorphism and for detecting "silent mutants", i.e. those...

Topics

Animals
Cattle
Dogs
Hemoglobins
Humans
Hydrogen-Ion Concentration
Isoelectric Focusing
Mice
Mutation
Peptide Mapping
Sheep

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Identifiers

PMID: 2806209
DOI: 10.1002/elps.1150100811

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2806209-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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