Article
Alpha-1 antitrypsin protease inhibitor typing in immobilized pH gradients.
Annals of clinical and laboratory science - 1 Jan 2000
Drobnies A E, Vaughan R
Abstract excerpt
Alpha-1 antitrypsin deficiency is a cause of liver disease in neonates and emphysema in adults. Protein phenotypes are identified by isoelectric focusing using polyacrylamide gels. The Pharmacia Phastsystem was utilized for electrophoresis in miniature gels to identify heterozygotes for the deficiency. Protein phenotypes were identified by isoelectric focusing in a fixed pH gradient from 4.3 to 5 using the...
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