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Murine systemic thrombophilia and hemolytic uremic syndrome from a factor H point mutation

5 Jan 2017

Abstract excerpt

Complement plays a key role in host defense, but its dysregulation can cause autologous tissue injury. Complement activation is normally controlled by regulatory proteins, including factor H (FH) in plasma and membrane cofactor protein (MCP) on the cell surface. Mutations in FH and MCP are linked to atypical hemolytic uremic syndrome, a type of thrombotic microangiopathy (TMA) that causes renal failure. We...

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Blood Coagulation and Thrombosis Mechanisms
Coagulation, Bradykinin, Polyphosphates, and Angioedema
Complement system in diseases

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 28057640
DOI: 10.1182/blood-2016-07-728253

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