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Article

The Chk2-PKM2 axis promotes metabolic control of vasculogenic mimicry formation in p53-mutated triple-negative breast cancer.

Oncogene - 1 Aug 2021

Yu Pei, Zhu Xiong, Zhu Jia-Le, Han Yu-Bao, Zhang Hao, Zhou Xiang, Yang Lei, Xia Yuan-Zheng, Zhang Chao, Kong Ling-Yi

Abstract excerpt

Vasculogenic mimicry (VM) formation, which participates in the process of neovascularization, is highly activated in p53-mutated triple-negative breast cancer (TNBC). Here, we show that Chk2 is negatively correlated with VM formation in p53-mutated TNBC. Its activation by DNA-damaging agents such as cisplatin, etoposide, and DPT reduces VM formation. Mechanistically, the Chk2-PKM2 axis plays an important role in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 34244606
DOI: 10.1038/s41388-021-01933-z

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