Article
Competitive binding of sulfamethazine and its N-acetylated metabolite.
Biopharmaceutics & drug disposition - 1 Jan 2000
Tsang Y C, Thiessen J J
Abstract excerpt
The protein binding of sulfamethazine (SMZ) was studied in rabbit serum. Serum solutions comprising various concentrations (approximately 0.01-3 mM) of SMZ and its major metabolite, N4-acetylsulfamethazine (AcSMZ), were prepared. These 'control' samples were also mixed via a Latin square design to study the interactive binding of SMZ and AcSMZ to the proteins. Equilibrium dialysis was conducted for 8 h....
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