Competitive binding of sulfamethazine and its N-acetylated metabolite.

doi:10.1002/bdd.2510100505

Back to search

Article

Competitive binding of sulfamethazine and its N-acetylated metabolite.

Biopharmaceutics & drug disposition - 1 Jan 2000

Tsang Y C, Thiessen J J

Abstract excerpt

The protein binding of sulfamethazine (SMZ) was studied in rabbit serum. Serum solutions comprising various concentrations (approximately 0.01-3 mM) of SMZ and its major metabolite, N4-acetylsulfamethazine (AcSMZ), were prepared. These 'control' samples were also mixed via a Latin square design t...

Topics

Acetylation
Animals
Binding, Competitive
Biotransformation
Blood Proteins
Buffers
Dialysis
Membranes, Artificial
Phenotype
Protein Binding
Rabbits
Sulfamethazine

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.