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Article

Multicellular spheroids from normal and neoplastic thyroid tissues as a suitable model to test the effects of multikinase inhibitors.

Oncotarget - 7 Feb 2017

Cirello Valentina, Vaira Valentina, Grassi Elisa Stellaria, Vezzoli Valeria, Ricca Dario, Colombo Carla, Bosari Silvano, Vicentini Leonardo, Persani Luca, Ferrero Stefano, Fugazzola Laura

Abstract excerpt

Multicellular three-dimensional (3D) spheroids represent an experimental model that is intermediate in its complexity between monolayer cultures and patients' tumor. In the present study, we characterize multicellular spheroids from papillary (PTC) and follicular (FTC) thyroid cancers and from the corresponding normal tissues. We show that these 3D structures well recapitulate the features of the original...

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Identifiers

PMID: 28039458
DOI: 10.18632/oncotarget.14187
PMCID: PMC5354768

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