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Article

Role of mouse hepatitis virus (MHV) receptor murine CEACAM1 in the resistance of mice to MHV infection: studies of mice with chimeric mCEACAM1a and mCEACAM1b.

Journal of virology - 1 Jul 2010

Hirai Asuka, Ohtsuka Nobuhisa, Ikeda Toshio, Taniguchi Rie, Blau Dianna, Nakagaki Keiko, Miura Hideka S, Ami Yasushi, Yamada Yasuko K, Itohara Shigeyoshi, Holmes Kathryn V, Taguchi Fumihiro

Abstract excerpt

Although most inbred mouse strains are highly susceptible to mouse hepatitis virus (MHV) infection, the inbred SJL line of mice is highly resistant to its infection. The principal receptor for MHV is murine CEACAM1 (mCEACAM1). Susceptible strains of mice are homozygous for the 1a allele of mCeacam1, while SJL mice are homozygous for the 1b allele. mCEACAM1a (1a) has a 10- to 100-fold-higher receptor activity than...

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Identifiers

PMID: 20410265
DOI: 10.1128/JVI.02680-09
PMCID: PMC2903249

Genes

CEACAM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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