Article
The protein level and transcription activity of activating transcription factor 1 is regulated by prolyl isomerase Pin1 in nasopharyngeal carcinoma progression.
Cell death & disease - 29 Dec 2016
Huang Guo-Liang, Liao Dan, Chen Hua, Lu Yan, Chen Liyong, Li Huahui, Li Binbin, Liu Weilong, Ye Caiguo, Li Tong, Zhu Zhu, Wang Jian, Uchida Takafumi, Zou Ying, Dong Zigang, He Zhiwei
Abstract excerpt
The function of activating transcription factor 1 (ATF1) and the mechanism about why ATF1 was over-phosphorylated in nasopharyngeal carcinoma (NPC) progression is completely undiscovered. In this study, a series of experiments both in vitro and in vivo were used to characterize a promotive function of ATF1 in NPC tumorigenesis and identify prolyl isomerase Pin1 as a novel regulator of ATF1 at post-transcription....
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