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Article

Toll-like receptor and hepatitis B virus clearance in chronic infected patients: a long-term prospective cohort study in Taiwan.

The Journal of infectious diseases - 1 Sept 2012

Wu Jia-Feng, Chen Chien-Hung, Ni Yen-Hsuan, Lin Ying-Ting, Chen Huey-Ling, Hsu Hong-Yuan, Chang Mei-Hwei

Abstract excerpt

BACKGROUND: We sought to elucidate the impacts of the Toll-like receptors (TLRs) on spontaneous hepatitis B virus (HBV) e antigen (HBeAg) and hepatitis B s antigen (HBsAg) seroconversion in chronic HBV-infected patients. METHODS: Human TLR2, TLR4, TLR5, and TLR9 gene polymorphisms were assessed in 278 HBeAg-positive, chronic HBV-infected patients. Additionally, HBV core antigen (HBcAg) in vitro stimulation using...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 22740716
DOI: 10.1093/infdis/jis420

Genes

TLR5
TLR9
TLR4
TLR2

Variants

rs4986790
rs5744174

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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