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Article

Capture-Based Targeted Ultradeep Sequencing in Paired Tissue and Plasma Samples Demonstrates Differential Subclonal ctDNA-Releasing Capability in Advanced Lung Cancer.

Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer - 1 Apr 2017

Mao Xiaowei, Zhang Zhou, Zheng Xiaoxuan, Xie Fangfang, Duan Feidie, Jiang Liyan, Chuai Shannon, Han-Zhang Han, Han Baohui, Sun Jiayuan

Abstract excerpt

INTRODUCTION: Circulating tumor DNA (ctDNA), which represents an unbiased way to assess tumor genetic profile noninvasively, facilitates studying intratumor heterogeneity. Although intratumor heterogeneity has been elucidated substantially in a few cancer types, including NSCLC, how it influences the ability of tumor cells harboring different genetic abnormalities in releasing their DNA remains elusive. We...

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Identifiers

PMID: 28007624
DOI: 10.1016/j.jtho.2016.11.2235

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