Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

LCN2 overexpression in bone enhances the hematopoietic compartment via modulation of the bone marrow microenvironment.

Journal of cellular physiology - 1 Nov 2017

Costa Delfina, Principi Elisa, Lazzarini Edoardo, Descalzi Fiorella, Cancedda Ranieri, Castagnola Patrizio, Tavella Sara

Abstract excerpt

Lipocalin-2 (LCN2) is a member of the lipocalin family whose expression is modulated in several conditions, including cell differentiation, innate immunity, stress, and cancer. Although it is known that it is expressed in bone, its function in this tissue remains poorly studied. To this end, we took advantage of transgenic mice lines that expressed LCN2 driven by a bone specific type I collagen (LCN2-Tg). In the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chemotaxis
Share to Collagen Type I

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Culture Media, Conditioned

Share to Lipocalin-2

Share to Paracrine Communication

Share to Peptide Hydrolases

Share to Stem Cell Niche

Source

Identifiers

PMID: 28004388
DOI: 10.1002/jcp.25755

Genes

LCN2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

LCN2 overexpression in bone enhances the hematopoietic compartment via modulation of the bone marrow microenvironment.PMID 28004388Read ↗

Lipocalin 2‐mediated growth suppression is evident in human erythroid and monocyte/macrophage lineage cellsSemantic proximity Read ↗

Lipocalin-2 Regulates Osteocyte Ferroptosis and Osteocyte-Osteoblast Crosstalk via Wnt Signaling to Control Bone FormationSemantic proximity Read ↗

Lipocalin 2: a new mechanoresponding gene regulating bone homeostasis.Semantic proximity Read ↗

Lipocalin 2 Influences Bone and Muscle Phenotype in the MDX Mouse Model of Duchenne Muscular Dystrophy.Semantic proximity Read ↗

A Complex Role for Lipocalin 2 in Bone Metabolism: Global Ablation in Mice Induces Osteopenia Caused by an Altered Energy Metabolism.Semantic proximity Read ↗

Overview of the expression patterns and roles of Lipocalin 2 in the reproductive systemSemantic proximity Read ↗

Lipocalin-2 expression in hypoxic murine osteocytes enhances RANKL-induced osteoclastogenesisSemantic proximity Read ↗

Lipocalin-2 contributes to experimental atherosclerosis in a stage-dependent manner.Semantic proximity Read ↗

BMP-2 generates a functional bone marrow niche by inducing the differentiation of local mesenchymal cells into CAR cellsSemantic proximity Read ↗

Lipocalin 2: A multifaceted modulator of human cancerSemantic proximity Read ↗

Lipocalin-2 Inhibits Osteosarcoma Cell Metastasis by Suppressing MET Expression via the MEK–ERK PathwaySemantic proximity Read ↗

Schlafen2 mutation in mice causes an osteopetrotic phenotype due to a decrease in the number of osteoclast progenitors.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.