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Article

Discovery of T Cell Receptor β Motifs Specific to HLA–B27–Positive Ankylosing Spondylitis by Deep Repertoire Sequence Analysis

21 Dec 2016

Abstract excerpt

OBJECTIVE: Ankylosing spondylitis (AS), a chronic inflammatory disorder, has a notable association with HLA-B27. One hypothesis suggests that a common antigen that binds to HLA-B27 is important for AS disease pathogenesis. This study was undertaken to determine sequences and motifs that are shared among HLA-B27-positive AS patients, using T cell repertoire next-generation sequencing. METHODS: To identify motifs...

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Share to Inflammatory Myopathies and Dermatomyositis
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 28002888
DOI: 10.1002/art.40028

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