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Article

Characterization of the Folding of a 52-Knotted Protein Using Engineered Single-Tryptophan Variants.

Biophysical journal - 20 Dec 2016

Zhang Hongyu, Jackson Sophie E

Abstract excerpt

An increasing number of proteins that contain topological knots have been identified over the past two decades; however, their folding mechanisms are still not well understood. UCH-L1 has a 52-knotted topology. Here, we constructed a series of variants that contain a single tryptophan at different locations along the polypeptide chain. A study of the thermodynamic properties of the variants shows that the...

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Identifiers

PMID: 28002735
DOI: 10.1016/j.bpj.2016.10.029
PMCID: PMC5192476

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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