Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Ribavirin suppresses bacterial virulence by targeting LysR-type transcriptional regulators.

Scientific reports - 19 Dec 2016

Mandal Rahul Shubhra, Ta Atri, Sinha Ritam, Theeya Nagaraja, Ghosh Anirban, Tasneem Mohsina, Bhunia Anirban, Koley Hemanta, Das Santasabuj

Abstract excerpt

Targeting bacterial virulence mechanisms without compromising bacterial growth is a promising strategy to prevent drug resistance. LysR-type transcriptional regulators (LTTRs) possess structural conservation across bacterial species and regulate virulence in numerous pathogens, making them attractive targets for antimicrobial agents. We targeted AphB, a Vibrio cholerae LTTR, which regulates the expression of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Drug Repositioning
Share to Ligands

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Molecular Conformation

Share to Rabbits

Share to Ribavirin

Share to Salmonella typhi

Share to Substrate Specificity

Share to Vibrio cholerae

Source

Open in PubMed Open full text

Identifiers

PMID: 27991578
DOI: 10.1038/srep39454
PMCID: PMC5171790

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Ribavirin suppresses bacterial virulence by targeting LysR-type transcriptional regulators.PMID 27991578Read ↗

Targeting agr- and agr-Like Quorum Sensing Systems for Development of Common Therapeutics to Treat Multiple Gram-Positive Bacterial InfectionsSemantic proximity Read ↗

Pathogen-associated gene discovery workflows for novel antivirulence therapeutic developmentSemantic proximity Read ↗

Structure, Biology, and Therapeutic Application of Toxin–Antitoxin Systems in Pathogenic BacteriaSemantic proximity Read ↗

Aurodox, a polyketide from <i>Streptomyces goldiniensis</i> , inhibits transcription of the type III secretion system of multiple Gram-negative pathogensSemantic proximity Read ↗

Drug-like Fragments Inhibit agr-Mediated Virulence Expression in Staphylococcus aureusSemantic proximity Read ↗

Computational exploration of natural compounds targeting Staphylococcus aureus : inhibiting AgrA promoter binding for antimicrobial interventionSemantic proximity Read ↗

Functional and Structural Diversity of Bacterial Contact-Dependent Growth Inhibition EffectorsSemantic proximity Read ↗

Alternate subunit assembly diversifies the function of a bacterial toxinSemantic proximity Read ↗

Targeting Gene Transcription Thwarts Antibiotic ResistanceSemantic proximity Read ↗

AphA is required for biofilm formation, motility, and virulence in pandemic Vibrio parahaemolyticus.Semantic proximity Read ↗

CdiA from Enterobacter cloacae delivers a toxic ribosomal RNase into target bacteria.Semantic proximity Read ↗

SarS Is a Repressor of Staphylococcus aureus Bicomponent Pore-Forming LeukocidinsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.