Article
A randomized comparison of dihydroartemisinin-piperaquine and artesunate-amodiaquine combined with primaquine for radical treatment of vivax malaria in Sumatera, Indonesia.
The Journal of infectious diseases - 1 Dec 2013
Pasaribu Ayodhia Pitaloka, Chokejindachai Watcharee, Sirivichayakul Chukiat, Tanomsing Naowarat, Chavez Irwin, Tjitra Emiliana, Pasaribu Syahril, Imwong Mallika, White Nicholas J, Dondorp Arjen M
Abstract excerpt
BACKGROUND: A high prevalence of chloroquine-resistant Plasmodium vivax in Indonesia has shifted first-line treatment to artemisinin-based combination therapies, combined with primaquine (PQ) for radical cure. Which combination is most effective and safe remains to be established. METHODS: We conducted a prospective open-label randomized comparison of 14 days of PQ (0.25 mg base/kg) plus either...
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