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Article

Histological transformation of ALK rearranged adenocarcinoma into small cell lung cancer: A new mechanism of resistance to ALK inhibitors.

Lung cancer (Amsterdam, Netherlands) - 1 Dec 2016

Levacq Delphine, D'Haene Nicky, de Wind Roland, Remmelink Myriam, Berghmans Thierry

Abstract excerpt

Various mechanisms of resistance to ALK inhibitors in ALK rearranged adenocarcinomas are reported including secondary gatekeeper mutations, bypass signaling or ALK amplifications as the commonest ones. We report a new mechanism of resistance with transformation of adenocarcinoma into small cell lung cancer. A 53-year-old non-smoker woman, experienced cancer progression after two lines of ALK inhibitors. A new...

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Identifiers

PMID: 27987586
DOI: 10.1016/j.lungcan.2016.10.012

Genes

ALK

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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