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Article

Myostatin propeptide mutation of the hypermuscular Compact mice decreases the formation of myostatin and improves insulin sensitivity.

American journal of physiology. Endocrinology and metabolism - 1 Mar 2017

Kocsis Tamas, Trencsenyi Gyorgy, Szabo Kitti, Baan Julia Aliz, Muller Geza, Mendler Luca, Garai Ildiko, Reinauer Hans, Deak Ferenc, Dux Laszlo, Keller-Pinter Aniko

Abstract excerpt

The TGFβ family member myostatin (growth/differentiation factor-8) is a negative regulator of skeletal muscle growth. The hypermuscular Compact mice carry the 12-bp Mstn(Cmpt-dl1Abc) deletion in the sequence encoding the propeptide region of the precursor promyostatin, and additional modifier genes of the Compact genetic background contribute to determine the full expression of the phenotype. In this study, by...

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PMID: 27965203
DOI: 10.1152/ajpendo.00216.2016

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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