Article
Stepwise pathogenic evolution of Mycobacterium abscessus.
Science (New York, N.Y.) - 30 Apr 2021
Bryant Josephine M, Brown Karen P, Burbaud Sophie, Everall Isobel, Belardinelli Juan M, Rodriguez-Rincon Daniela, Grogono Dorothy M, Peterson Chelsea M, Verma Deepshikha, Evans Ieuan E, Ruis Christopher, Weimann Aaron, Arora Divya, Malhotra Sony, Bannerman Bridget, Passemar Charlotte, Templeton Kerra, MacGregor Gordon, Jiwa Kasim, Fisher Andrew J, Blundell Tom L, Ordway Diane J, Jackson Mary, Parkhill Julian, Floto R Andres
Abstract excerpt
Although almost all mycobacterial species are saprophytic environmental organisms, a few, such as Mycobacterium tuberculosis, have evolved to cause transmissible human infection. By analyzing the recent emergence and spread of the environmental organism M. abscessus through the global cystic fibrosis population, we have defined key, generalizable steps involved in the pathogenic evolution of mycobacteria. We show...
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