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Article

Molecular-intelligence correlations in young fragile X males with a mild CGG repeat expansion in the FMR1 gene.

American journal of medical genetics - 9 Aug 1996

Steyaert J, Borghgraef M, Legius E, Fryns J P

Abstract excerpt

Several mechanisms can explain the occurrence of full-mutation fragile X males with an IQ level above -2 SD below mean, also called "high-functioning fragile X males." Incomplete methylation of the CpG island at the 5' end of the FMR1 gene is one of these mechanisms. The present study describes the physical and behavior phenotypes in 7 fragile X boys with CGG repeat insertions in the FMR1 gene between 600-2,400...

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Identifiers

PMID: 8844064
DOI: 10.1002/(SICI)1096-8628(19960809)64:2<274::AID-AJMG8>3.0.CO;2-U

Genes

FMR1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Molecular-intelligence correlations in young fragile X males with a mild CGG repeat expansion in the FMR1 gene.PMID 8844064Read ↗

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A deletion of 1.6 Kb proximal to the CGG repeat of the FMR1 gene causes fragile X-like psychological features.Semantic proximity Read ↗

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Tissue mosaicism, FMR1 expression and intellectual functioning in males with fragile X syndrome.Semantic proximity Read ↗

Contribution of the FMR1 gene mutation to human intellectual dysfunction.Semantic proximity Read ↗

Evidence that methylation of the FMR-I locus is responsible for variable phenotypic expression of the fragile X syndrome.Semantic proximity Read ↗

Clinical aspects of the fragile X syndrome.Semantic proximity Read ↗

FMR1 Protein Expression Correlates with Intelligence Quotient in Both Peripheral Blood Mononuclear Cells and Fibroblasts from Individuals with an FMR1 Mutation.Semantic proximity Read ↗

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Mosaicism for a full mutation, premutation, and deletion of the CGG repeats results in 22% FMRP and elevated FMR1 mRNA levels in a high-functioning fragile X male.Semantic proximity Read ↗

CGG repeat expansion at FMR1 locus - A new molecular diagnostic algorithm in fragile X syndrome.Semantic proximity Read ↗

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