Article
Molecular-intelligence correlations in young fragile X males with a mild CGG repeat expansion in the FMR1 gene.
American journal of medical genetics - 9 Aug 1996
Steyaert J, Borghgraef M, Legius E, Fryns J P
Abstract excerpt
Several mechanisms can explain the occurrence of full-mutation fragile X males with an IQ level above -2 SD below mean, also called "high-functioning fragile X males." Incomplete methylation of the CpG island at the 5' end of the FMR1 gene is one of these mechanisms. The present study describes t...
Topics
- Adolescent
- Child
- DNA
- DNA Methylation
- DNA Transposable Elements
- Dinucleoside Phosphates
- Fragile X Mental Retardation Protein
- Fragile X Syndrome
- Humans
- Intelligence
- Lymphocytes
- Male
- Nerve Tissue Proteins
- Phenotype
- RNA-Binding Proteins
- Trinucleotide Repeats