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Article

Huntingtin polyQ Mutation Impairs the 17β-Estradiol/Neuroglobin Pathway Devoted to Neuron Survival.

Molecular neurobiology - 1 Oct 2017

Nuzzo Maria Teresa, Fiocchetti Marco, Totta Pierangela, Melone Mariarosa A B, Cardinale Antonella, Fusco Francesca R, Gustincich Stefano, Persichetti Francesca, Ascenzi Paolo, Marino Maria

Abstract excerpt

Among several mechanisms underlying the well-known trophic and protective effects of 17β-estradiol (E2) in the brain, we recently reported that E2 induces the up-regulation of two anti-apoptotic and neuroprotectant proteins: huntingtin (HTT) and neuroglobin (NGB). Here, we investigate the role of this up-regulation. The obtained results indicate that E2 promotes NGB-HTT association, induces the localization of...

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Identifiers

PMID: 27957684
DOI: 10.1007/s12035-016-0337-x

Genes

HTT
NGB

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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