Article
Population Pharmacokinetic Modeling of Tenofovir in the Genital Tract of Male HIV-Infected Patients.
Antimicrobial agents and chemotherapy - 1 Mar 2017
Valade Elodie, Bouazza Naïm, Lui Gabrielle, Illamola Silvia M, Benaboud Sihem, Treluyer Jean-Marc, Cobat Aurélie, Foissac Frantz, De Sousa Mendes Maïlys, Chenevier-Gobeaux Camille, Suzan-Monti Marie, Rouzioux Christine, Assoumou Lambert, Viard Jean-Paul, Urien Saïk, Ghosn Jade, Hirt Déborah
Abstract excerpt
The aims of this study were to describe the blood plasma (BP) and seminal plasma (SP) pharmacokinetics of tenofovir (TFV) in HIV-1-infected men, to assess the role of genetic polymorphism in the variability of TFV transfer into the male genital tract, and to evaluate the impact of TFV SP exposure on seminal plasma HIV load (spVL). Men from the Evarist-ANRS EP 49 study treated with TFV as part of their...
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