Article
A novel motif in fungal class 1 histone deacetylases is essential for growth and development of Aspergillus.
Molecular biology of the cell - 15 Jan 2010
Tribus Martin, Bauer Ingo, Galehr Johannes, Rieser Gudrun, Trojer Patrick, Brosch Gerald, Loidl Peter, Haas Hubertus, Graessle Stefan
Abstract excerpt
Acetylation of the N-terminal tails of core histones is an important regulatory mechanism in eukaryotic organisms. In filamentous fungi, little is known about the enzymes that modify histone tails. However, it is increasingly evident that histone deacetylases and histone acetyltransferases are critical factors for the regulation of genes involved in fungal pathogenicity, stress response, and production of...
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