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Article

RASopathies Are Associated With Delayed Puberty; Are They Associated With Precocious Puberty Too?

Pediatrics - 1 Dec 2016

van der Kaay Daniëlle C M, Levine Bat-Sheva, Doyle Daniel, Mendoza-Londono Roberto, Palmert Mark R

Abstract excerpt

RASopathies, such as Noonan, Costello, and cardio-facio-cutaneous syndromes, are developmental disorders caused by mutations in rat sarcoma-mitogen-activated protein kinase pathway genes. Mutations that cause Noonan syndrome have been associated with delayed puberty. Here we report 4 patients with either Costello or cardio-facio-cutaneous syndrome who developed precocious puberty, suggesting complex regulation of...

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Identifiers

PMID: 27940666
DOI: 10.1542/peds.2016-0182

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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