Article
Delayed Puberty Phenotype Observed in Noonan Syndrome Is More Pronounced in Girls than Boys.
Hormone research in paediatrics - 1 Jan 2022
Rezende Raissa C, Noronha Renata Maria, Keselman Ana, Quedas Elisangela P S, Dantas Naiara C B, Andrade Nathalia L M, Bertola Debora R, Malaquias Alexsandra C, Jorge Alexander A L
Abstract excerpt
INTRODUCTION: Pubertal delay is described as one of the clinical features in Noonan syndrome (NS) and it may be one of the factors causing short adult height in those patients. The present study aimed at characterizing pubertal development in NS and identifying pubertal delay predictors. METHODS: We analyzed 133 individuals with a molecular diagnosis of NS and clinical puberty evaluation. We characterized delayed...
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