Article
A candidate regulatory variant at the TREM gene cluster associates with decreased Alzheimer's disease risk and increased TREML1 and TREM2 brain gene expression.
Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Jun 2017
Carrasquillo Minerva M, Allen Mariet, Burgess Jeremy D, Wang Xue, Strickland Samantha L, Aryal Shivani, Siuda Joanna, Kachadoorian Michaela L, Medway Christopher, Younkin Curtis S, Nair Asha, Wang Chen, Chanana Pritha, Serie Daniel, Nguyen Thuy, Lincoln Sarah, Malphrus Kimberly G, Morgan Kevin, Golde Todd E, Price Nathan D, White Charles C, De Jager Philip L, Bennett David A, Asmann Yan W, Crook Julia E, Petersen Ronald C, Graff-Radford Neill R, Dickson Dennis W, Younkin Steven G, Ertekin-Taner Nilüfer
Abstract excerpt
INTRODUCTION: We hypothesized that common Alzheimer's disease (AD)-associated variants within the triggering receptor expressed on myeloid (TREM) gene cluster influence disease through gene expression. METHODS: Expression microarrays on temporal cortex and cerebellum from ∼400 neuropathologically diagnosed subjects and two independent RNAseq replication cohorts were used for expression quantitative trait locus...
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