Article
Antecedents of New-Onset Major Depressive Disorder in Children and Adolescents at High Familial Risk.
JAMA psychiatry - 1 Feb 2017
Rice Frances, Sellers Ruth, Hammerton Gemma, Eyre Olga, Bevan-Jones Rhys, Thapar Ajay K, Collishaw Stephan, Harold Gordon T, Thapar Anita
Abstract excerpt
Importance: Early-onset major depressive disorder (MDD) is common in individuals at high familial risk of depression and is associated with poor long-term mental health, social, and educational outcomes. Objectives: To examine the developmental pathways that lead to first-episode adolescent-onset MDD (incident cases) in those at high familial risk and to postulate a theoretically informed model that enables...
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