The risks for major psychiatric disorders in the siblings of probands with major depressive disorder.

doi:10.1038/s41380-024-02650-1

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Article

The risks for major psychiatric disorders in the siblings of probands with major depressive disorder.

Molecular psychiatry - 1 Jan 2025

Rhee Sang Jin, Abrahamsson Linda, Sundquist Jan, Sundquist Kristina, Kendler Kenneth S

Abstract excerpt

Using a case-controlled study including siblings of major depression (MD) and control probands, born 1970-1990 and followed through 2018, we sought to clarify the degree to which the familial liability to MD is reflected in its clinical features, and the pattern of psychiatric disorders at elevated risk in the siblings of MD probands. The study population included full-siblings of 197,309 MD and matched 197,309...

Topics

Humans
Siblings
Male
Major Depressive Disorder
Female
Adult
Case-Control Studies
Risk Factors
Anxiety Disorders
Middle Aged
Mental Disorders

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Bipolar Disorder

Attention Deficit Disorder with Hyperactivity

Genetic Predisposition to Disease

Proportional Hazards Models

Obsessive-Compulsive Disorder

Alcoholism

Source

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Identifiers

PMID: 38972942
DOI: 10.1038/s41380-024-02650-1
PMCID: PMC11649559

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