Article
Moderate hyperoxia induces extracellular matrix remodeling by human fetal airway smooth muscle cells.
Pediatric research - 1 Feb 2017
Vogel Elizabeth R, Britt Rodney D, Faksh Arij, Kuipers Ine, Pandya Hitesh, Prakash Y S, Martin Richard J, Pabelick Christina M
Abstract excerpt
BACKGROUND: Premature infants are at increased risk for airway diseases, such as wheezing and asthma, because of early exposure to risk factors including hyperoxia. As in adult asthma, airway remodeling and increased extracellular matrix (ECM) deposition is involved. METHODS: We assessed the impact of 24-72 h of moderate hyperoxia (50%) on human fetal airway smooth muscle (fASM) ECM deposition through western...
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