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Article

Neonatal periostin knockout mice are protected from hyperoxia-induced alveolar simplication.

PloS one - 1 Jan 2012

Bozyk Paul D, Bentley J Kelley, Popova Antonia P, Anyanwu Anuli C, Linn Marisa D, Goldsmith Adam M, Pryhuber Gloria S, Moore Bethany B, Hershenson Marc B

Abstract excerpt

In bronchopulmonary dysplasia (BPD), alveolar septae are thickened with collagen and α-smooth muscle actin, transforming growth factor (TGF)-β-positive myofibroblasts. Periostin, a secreted extracellular matrix protein, is involved in TGF-β-mediated fibrosis and myofibroblast differentiation. We hypothesized that periostin expression is required for hypoalveolarization and interstitial fibrosis in...

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Source

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Identifiers

PMID: 22363622
DOI: 10.1371/journal.pone.0031336
PMCID: PMC3281961

Genes

CCL4
CXCL1
CXCL2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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