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Article

The CXCL12/CXCR4 Signaling Pathway: A New Susceptibility Factor in Human Papillomavirus Pathogenesis.

PLoS pathogens - 1 Dec 2016

Meuris Floriane, Carthagena Laetitia, Jaracz-Ros Agnieszka, Gaudin Françoise, Cutolo Pasquale, Deback Claire, Xue Yuezhen, Thierry Françoise, Doorbar John, Bachelerie Françoise

Abstract excerpt

The productive human papillomavirus (HPV) life cycle is tightly linked to the differentiation and cycling of keratinocytes. Deregulation of these processes and stimulation of cell proliferation by the action of viral oncoproteins and host cell factors underlies HPV-mediated carcinogenesis. Severe HPV infections characterize the wart, hypogammaglobulinemia, infection, and myelokathexis (WHIM) immunodeficiency...

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Share to Cell Transformation, Viral
Share to Chemokine CXCL12

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Human papillomavirus 18

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Share to Receptors, CXCR4

Source

Open in PubMed Open full text

Identifiers

PMID: 27918748
DOI: 10.1371/journal.ppat.1006039
PMCID: PMC5138052

Genes

CXCR4
CXCL12

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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